Gary Lindquester

Professor of Biology
(901) 843-3564

RESEARCH INTERESTS

Molecular Biology, Virology, Immunology

Dr. Lindquester studies the role of a protein known as interleukin 10 (IL-10) that is produced by the human pathogen, Epstein Barr virus (EBV). He and his students generated a recombinant murine gammaherpesvirus containing the EBV IL-10 gene to study its effects on infection, latency, and pathogenesis in a mouse animal model.  They found that expression of this gene increases acute pathogenesis of the virus as measured by enhanced enlargement of the spleen and increased virus production; however, it does not affect the establishment of latency or reactivation. The specific mechanism by which expression of the viral IL-10 gene enhances acute pathogenesis remains to be determined.

SELECTED PUBLICATIONS

Refereed Papers

Epstein-Barr Virus IL-10 Gene Expression by a Recombinant Murine Gammaherpesvirus in Vivo Enhances Acute Pathogenicity but Does Not Affect Latency or Reactivation.  G.J. Lindquester, K.A. Greer*, J.P. Stewart and J.T. Sample, Herpesviridae, 5:1-, 2014.

Developing Information Fluency in Introductory Biology Students in the Context of an Investigative Laboratory. Gary J. Lindquester, Romi L. Burks, and Carolyn R. Jaslow, Cell Biology Education, 4:58-96, 2005.

Analysis of Equine Herpesvirus 2 Strain Variation Using Monoclonal Antibodies to Glycoprotein B. S.A. Holloway, G.J. Lindquester, M.J. Studdert, and H.E. Drummer, Archives of Virology, 145: 1699-1713, 2000.

Identification, Sequence Analysis and Characterisation of Equine Herpesvirus 5 gB.  S.A. Holloway, G.J. Lindquester,  M.J. Studdert, and H.E. Drummer, Archives of Virology, 144: 287-307, 1999.

Genetic Content of a 20.9 kb Segment of Human Herpesvirus 6B Strain Z29 Spanning the Homologs of Human Herpesvirus 6A Genes U40-57 and Containing the Origin of DNA Replication. G.J. Lindquester, J.J. O’Brian, E.D. Anton, C.A. Greenamoyer, P.E. Pellett, and T.R. Dambaugh, Archives of Virology, 142:103-123, 1997.

Comparison of a 20kb Region of Human Herpesvirus 6B with Other Human Betaherpesviruses Reveals Conserved Replication Genes and Adjacent Divergent Open Reading Frames. G.J. Lindquester, C.A. Greenamoyer, E.D. Anton, J.J. O’Brian, P.E. Pellett, and T.R. Dambaugh, Archives of Virology, 142:193-204, 1997.

Restriction Endonuclease Mapping and Molecular Cloning of the Human Herpesvirus 6 Variant B Strain Z29 Genome. G. J. Lindquester, N. Inoue, R.D. Allen*,  J.W. Castelli*, F.R. Stamey, T.R. Dambaugh, J.J. O’Brian, R.M. Danovitch, N. Frenkel, and P. E. Pellett, Archives of Virology, 141:367-379, 1996.

Properties of the Human Herpesvirus 6 Strain Z29 Genome: G+C Content, Length, and Presence of Variable-Length Directly Repeated Terminal Sequence Elements. Gary          J. Lindquester and Philip E. Pellett, Virology 182:102-110, 1991.

Genomic Heterogeneity of Human Herpesvirus 6 Isolates. Philip E. Pellett, Gary J. Lindquester, Paul Feorino, and Carlos Lopez, Adv. Exp. Med. Biol. 278:9-18, 1990.

*Rhodes student co-author

 

Education

B.S. in Biology, 1981, Furman University, Greenville, SC
M.S. in Biology, 1985, Emory University, Atlanta, GA 
Ph.D. in Biology, 1986, Emory University, Atlanta, GA 
(Molecular biology, virology, immunology)