Dr. Loretta Jackson-Hayes Research Group, Fungal Growth Biochemistry and Molecular Biology
Our laboratory focuses on mechanisms of eukaryotic gene expression. Currently, we are focusing on genes and proteins that are involved in fungal cell wall metabolism. The fungal cell wall, which is composed of polysaccharides and glycoproteins, is essential for fungal growth and is an excellent target for antifungal drugs and fungicides. Knowledge regarding fungal growth can be used to inform scientists, doctors, farmers, and fungi-related industries on how to control their growth. We have identified several genes that play specific roles in cell wall metabolism in the filamentous fungus Aspergillus nidulans. Experiments are being conducted to investigate the regulation of message production of these genes, to observe the cellular localization of the proteins during different stages of fungal development, and to learn more about the specific role of each of them in cell wall metabolism.
Current Group Members
Loretta Jackson-Hayes, Zainab O. Atiq, Brianna Betton, W. Toler Freyaldenhoven, Lance Myers, Elisabet Olsen, Terry W. Hill. (2019) “Aspergillus nidulans protein kinase C forms a complex with the formin SepA that is involved in apical growth and septation.” Fungal Genetics and Biology, 122, 21-30.
Loretta Jackson-Hayes, Terry W. Hill, Darlene M. Loprete, Claire DelBove, Justin Shapiro, Jordan Henley, and Omolola Dawodu. (2015) “Two amino acid sequences direct Aspergillus nidulans protein kinase C (PkcA) localization to hyphal apices and septation sites.” Mycologia, 107(3), 452-459.